Acid is NOT
the Problem.

A new, mechanism-driven approach to reflux is here.

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From the Developers of Atrantil

Re:flux™ is the first gastroenterologist-developed, natural treatment for acid reflux that targets the root causes for lasting relief. Acid Reflux Relief, reimagined.

Re:flux® Acid Reflux Relief

Polyphenol-Powered Relief from occasional heartburn, indigestion, and burning discomfort.

Formulated by a Board-Certified Gastroenterologist

Re:flux® is designed to support balance in your digestive system. t does not shut acid down, and it does not artificially increase it. Instead, it works with your body to help digestion function the way it was meant to.

When stomach contents move downward efficiently and the natural barrier between the stomach and esophagus is supported, occasional burning and irritation can begin to settle.

This is a systems-focused approach to reflux.
Not acid suppression.
Not acid boosting.
Balance.

How To Use

Take 2 capsules twice a day, preferably before meals.

Important if you are on reflux medication:
Healing a system is not always linear, especially if you have been on reflux medication for years. Any change to a PPI, purple pill, or other acid-blocker should be done slowly and in partnership with your doctor or healthcare provider. If you are currently on one of these medications, do not stop suddenly. Instead, check out our PPI weaning protocol and use it as a guide for that conversation.

What To Expect

Re:flux is a systems-level approach, not a symptom-chaser. It works with your gut and reflux mechanics over time as your body relearns how to regulate itself.

Weeks 1 to 2: Foundation phase
Support starts to kick in. Many people notice less burning, bloating, and regurgitation.

Weeks 3 to 8: Deeper system shifts
Motility and tissue support deepen. If you and your healthcare provider decide to start weaning off a PPI, this is often when rebound shows up, which is why staying consistent with Re:flux and lifestyle support matters most here.

Week 9 and beyond: New baseline
You are managing, not just reacting. Many people reduce or come off PPIs and lean on Re:flux daily or as needed during periods of stress or dietary changes.

Healing a system takes time, especially if reflux has been part of your life for years. Re:flux is designed to support that longer arc of change, not just a single bad day.

Want the full week-by-week breakdown? [Learn more about the Re:flux timeline].

PPI Weaning Protocol

If you are currently taking a PPI, it is important not to stop suddenly.

Coming off proton pump inhibitors (PPIs) usually requires a step-down plan to avoid rebound acid and symptom flare-ups. Always consult with your healthcare provider before changing any prescription medication.

Click here for our step-by-step PPI weaning protocol.

Polyphenol Science

Polyphenols are powerful plant compounds found in citrus, roots, and botanicals that help your gut do what it is meant to do. Instead of shutting acid off, they support motility, calm inflammation, protect delicate tissues, and help keep stomach contents moving in the right direction. The polyphenols in Re:flux were chosen and combined to restore balance to the whole system, not just silence symptoms.

Read more about Polyphenols here.

Clinically Proven

In a recent clinical analysis conducted within a gastroenterology practice, a formulation containing hesperidin, noni, dandelion, and atractylodes demonstrated meaningful improvements in reflux-related symptoms over a four week period:

81% of patients reported complete resolution of symptoms

91.5% experienced clinically meaningful improvement (≥75%)

79.3% of patients discontinued acid-suppressing medications

This data supports a mechanism-based approach that focuses on restoring function rather than simply suppressing acid.

CLINICAL STUDY

Trusted by Over Two Million Guts.
Now, We’re Tackling Reflux.

After helping millions improve their gut health with Atrantil, board-certified gastroenterologist Dr. Ken Brown, MD, saw the need for a new approach to acid reflux. Instead of shutting down what the body needs, he built on proven polyphenol science to create Reflux™, a natural solution that targets the root causes rather than just masking the symptoms. And we proved it clinically.

Be Among the First to Pre-order Re:flux™
Launching in 2026.

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Why Re:flux™ is a Breakthrough in Acid Reflux Relief

Because Re:flux™ targets four mechanisms behind acid reflux, it:

1. Strengthens LES Tone: Supports acetylcholine and GABA pathways to improve lower esophageal sphincter function, reducing backflow of acid.

2. Restores Motility (MMC Activation): Activates 5-HT4 receptors to enhance migrating motor complex activity, promoting proper gastric emptying and motility rhythm.

3. Regulates Acid & Histamine: Balances histamine and H2 receptor activity, maintaining healthy acid levels without suppression.

4. Reduces Inflammation & Oxidative Stress: Polyphenol-rich extracts (Hesperidin, Noni, Dandelion, Atractylodes) decrease gut inflammation, support mucosal integrity, and protect epithelial tissue.

Why Re:flux Works When Other Treatments Don’t.

Re:flux isn’t a band-aid. It’s safe for daily use and works with your body to restore balance — giving lasting relief that other treatments can’t.

Clinical Action Re:flux Antacids Blocker Alginates Prokinetics Natural Remedies
Fast Symptom Relief (slower)
Reduces/Rebalances Acid (buffers without suppression) (buffers only) (moderate)
Protects LES (Valve)
Improves Motility / Emptying Some
Safe for Long-Term Use (mineral imbalance) (nutrient malabsorption) (short-term only) (side effects, limited use) (lifestyle dependent)
Maintains Nutrient Absorption
Addresses Root Causes Partial Partial
5 Black Stars

“I drank coffee for the first time in years and cried. That was the biggest thing for me.”

Clinical Trial Participant

5 Black Stars

“I took it with me to Italy and was able to enjoy wine and food again.”

Clinical Trial Participant

5 Black Stars

“As long as I take Re:flux, I can eat a bit more freely and sleep through the night.”

Clinical Trial Participant

Why You Should Break Up With Your PPIs

They say it’s love, but it’s really just suppression.
Break free from your PPIs and their long-term side effects.

PPI Weaning Protocol

Sign Up for Early Access. Practitioners & Patients Welcome

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Polyphenol Science

As the developers of Atrantil, we’ve been at the forefront of Polyphenol Science for decades, revolutionizing digestive health naturally. These clinically studied plant compounds work in synergy to restore balance and protect your gut. Re:flux is safe for long-term use and free of side effects.